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Due to these toxic effects of mutant SOD1 on mitochondria, it has been proposed that the abnormal activity of the mitochondria in ALS may account for the initiation and progression of the disease

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These studies suggest that ammonium accumulation may induce programmed cell death of immune cells within TME, such as NK cells, through oxidative imbalance and mitochondria-mediated autophagy, thereby promoting immune evasion by prostate cancer cells